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. 2013 Dec 15;1(7):e00181. doi: 10.1002/phy2.181

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (A) Representative histological images of trichrome‐stained renal sections; (I) Smad3 WT non‐TGF‐β1, (II) Smad3 WT TGF‐β1, (III) Smad3 KO non‐TGF‐β1, and (IV) Smad3 KO TGF‐β1 mice. Note that glomerular as well as tubular interstitial accumulation of collagen is mainly seen in Smad3 WT TGF‐β1 mice (arrows) (original magnification: 40×). (B) A semiquantitative analysis of trichrome amount in the glomerulus is shown (*^#P < 0.05 vs. Smad3 WT TGF‐β1 mice) (n = 6/group). (C) A semiquantitative analysis of trichrome amount in the interstitium is shown (*^#P < 0.05 vs. Smad3 WT TGF‐β1 mice) (n = 6/group).