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. 2013 Dec 15;1(7):e00181. doi: 10.1002/phy2.181

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — The response of murine mesangial (SV40 MES 13) and glomerular endothelial cells to TGF‐β1 (2 ng/mL) alone or in combination with the Smad2/3 inhibitor (A83‐01). TGF‐β1 stimulates collagen α1(IV) (A), MMP‐2 (B), and TIMP‐1 (C) mRNA expression in the mesangial cells and collagen type α3(IV) (D), MMP‐2 (E), MMP‐9 (F), and TIMP‐1 (G) mRNA expression in the glomerular endothelial cells. These effects are all reversed by addition of A83‐01 inhibitor (*P < 0.05 vs. TGF‐β1 group) (n = 6 wells/treatment/group). MMP‐2, matrix metalloproteinase‐2; MMP‐9, matrix metalloproteinase‐9; TIMP‐1, tissue inhibitors of metalloproteinase‐1.