Table 5.
Topical drugs | Control group | Accrual period | Population | Place study undertaken | Projected ventilator or ICU time | Timing of outcome | |
---|---|---|---|---|---|---|---|
Bergmans44 | Gentamicin, Polymyxin, Vancomycin / QDS | Placebo | Sep 1994-Dec 1996 | Mixed ICU, all ventilated | Multiple sites (3), Netherlands | >48 hr of mechanical ventilation | ICU discharge |
Pugin45 | Polymyxin, Neomycin, Vancomycin / 4 hourly | Placebo | Apr-Nov 1989 | Surgical ICU, all ventilated | Geneva, Switzerland | >48 hr of intubation | Hospital discharge |
Rios46 | Polymyxin, Gentamicin / TDS | Placebo | Uncertain | Uncertain | Buenos Aires, Argentina | >4 days of mechanical ventilation | Unclear |