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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Metabolism. 2013 Jan 26;62(6):873–887. doi: 10.1016/j.metabol.2013.01.001

Fig. 5.

Fig. 5

Upstream molecular signaling pathways for the expression of p27 were down-regulated in the livers from homozygous leptin-deficient obese ob/ob mice compared with heterozygous lean control mice. By contrast, the direction of the changes in the hepatic expression of these proteins was opposite in homozygous long-lived Ames dwarf mice compared with heterozygous Ames normal control mice. Hepatic expression of (A) total 4E-BP1 (n=3 each for experimentals and controls), (B) 4E-BP1 phosphorylated at Thr37/46 (n=3 each for experimentals and controls), (C) total S6K1 (n=3 each for experimentals and controls) and (D) S6K1 phosphorylated at Thr389 (n=3 each for experimentals and controls), (E) total AMPKα (n=3 each for experimentals and controls), (F) AMPKα phosphorylated at Thr172 (n=3 each for experimentals and controls), and (G) SIRT3 (n=3 each for experimentals and controls) in the homozygous leptin-deficient obese ob/ob mice, heterozygous lean control mice, homozygous long-lived Ames dwarf mice and heterozygous Ames normal control mice.