Table 4.
Bombesin analogs labeled supramolecular aggregates or nanoparticles
| Peptide sequence | Peptide conjugation | Aggregates and lipid composition | Drug | References |
|---|---|---|---|---|
| [7–14] BN QWAVGHML-NH2 |
BN amphiphilic solid phase synthesis | Liposome: (C18)2DOTA/(C18)2(AdOO)5BN and (C18)2DOTA/(C18)2Peg3000BN (9:1 molar ratio) | DOX | 98 |
| [7–14] BN QWAVGHML-NH2 |
BN amphiphilic solid phase synthesis | Liposome: DSPC/MonY-BN (1:0.03 molar ratio) | DOX | 99 |
| AhoH-DPheQWAVNMeGHSta-L-NH2 | BN analog amphiphilic solid phase synthesis | Liposome: DSPC/MonY-BN-AA1 (1:0.03 molar ratio) | DOX | 101 |
| Ac-Cys-Ahx-QWAVGHLMNH2 | Ac-Cys-Ahx-BN NH2-AuNP |
AuNPs | 104 | |
| 7–14 BN QWAVGHML-NH2 |
7–14 BN functionalized on N-terminus with lipoic acid AuNPs |
AuNPs | 103 |
Abbreviations: AdOO, 8-amino-3,6-dioxaoctanoic acid; AhOH, 21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; AuNP, gold nanoparticles; Ahx, aminohexanoic acid; BN, bombesin; DOX, doxorubicin; DSPC, 1,2-Distearoyl-sn-glycero-3-phosphocholine.