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In vitro effects of SEI003 and aprotinin on KLK and human total stratum corneum protease activity. (A) Both SEI003 and aprotinin inhibit KLK activity compared to vehicle alone. SEI003 completely blocks KLK activity for the first 45 minutes of the assay. (B) Compared to vehicle alone, SEI003 and aprotinin both significantly decrease stratum corneum protease activity.
