Table 1.
Randomized controlled trials grouped according to qualifying vascular event
| n | Population | Mean age |
Male (%) |
Mean follow-up |
Jadad score |
|
|---|---|---|---|---|---|---|
| Stable vascular disease trials | ||||||
| ACTIVE A 2009 (4) | 7 554 | Atrial fibrillation | 71 | 58 | 3·6 years | 5 |
| CHARISMA 2006 (5) | 15 603 | Cardiovascular disease or multiple risk factors | 68 | 70 | 2·3 years | 5 |
| PROCLAIM 2009 (6) | 181 | Metabolic syndrome | 56 | 43 | 6 weeks | 5 |
| REAL-LATE/ZEST-LATE 2010 (7) | 2 701 | Coronary artery stents >12 months before | 62 | 70 | 1·6 years | 3 |
| SPS3 2012 (8) | 3 020 | Recent lacunar stroke | 63 | 63 | 3·5 years | 5 |
| Combined | 29 059 | 64 | 61 | 2·7 years | – | |
| Recent vascular event (≤30 days) | ||||||
| CARESS 2005 (9) | 107 | Recently symptomatic carotid stenosis | 60 | 78 | 7 days | 4 |
| CLAIR 2010 (10) | 100 | Stroke/TIA within 7 days and intracranial stenosis | 57 | 38 | 7 days | 3 |
| COMMIT 2005 (11) | 45 852 | Acute myocardial infarct | 61 | 72 | 15 days | 5 |
| CURE 2001 (12) | 12 562 | Acute coronary syndromes within <24 h | 64 | 70 | 9 months | 5 |
| FASTER 2007 (13) | 392 | TIA within 24 h or minor ischemic stroke | 68 | 54 | 90 days | 5 |
| Combined | 59 013 | 62 | 62 | 71 days | – | |
| Perioperative/periprocedural | ||||||
| CASCADE 2010 (14) | 113 | Coronary artery bypass grafting | 67 | 89 | 1 years | 5 |
| Cassar et al. 2005 (15) | 132 | Lower extremity bypass surgery | 66 | 77 | 30 days | 5 |
| CREDO 2002 (16) | 2 116 | Coronary stenting | 62 | 71 | 1 years | 5 |
| Combined | 2 361 | 65 | 79 | 11·4 months | – | |
| Overall results | ||||||
| 13 trials above | 90 433 | 63 | 66 | 1·0 years | – |
TIA, transient ischemic attack.