Table 5.
Effect of adding clopidogrel to aspirin in patients with recent brain ischemia (≤ 30 days)
| All stroke | Ischemic + unknown etiology | Major haemorrhage | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Trial | n | CPD + ASA | ASA | OR (95% CI) | CPD + ASA | ASA | OR (95% CI) | CPD + ASA | ASA | OR (95% CI) |
| CARESS 2005 (9) | 107 | 0 | 4 | 0·11 (0·006–2·16) | 0 | 4 | 0·11 (0·006–2·16) | 0 | 0 | 1·10 (0·02–56) |
| CHARISMA sub-group 2011 (17) | 1331 | 34 | 46 | 0·73 (0·46–1·15) | 32 | 43 | 0·74 (0·46–1·18) | 9 | 11 | 0·82 (0·34–1·99) |
| CLAIR 2010 (10) | 100 | 0 | 2 | 0·22 (0·01–4·63) | 0 | 2 | 0·22 (0·01–4·63) | 0 | 0 | 1·13 (0·02–58) |
| FASTER 2007 (13) | 392 | 14 | 21 | 0·63 (0·31–1·27) | 12 | 21 | 0·53 (0·25–1·11) | 1 | 0 | 2·95 (0·12–73) |
| Meta-analysis | 1930 | 48 | 73 | 0·67 (0·46–0·97) | 44 | 70 | 0·64 (0·43–0·94) | 10 | 11 | 0·91 (0·40–2·07) |
A total of seven intracerebral haemorrhages were reported in the four trials: four assigned to combination (two in CHARISMA sub-study and two in FASTER) and three assigned to aspirin alone (all in CHARISMA sub-group); meta-analysis OR 1·12 (0·29–4·32).
CPD, clopidogrel; ASA, aspirin; OR, odds ratio; CI, confidence interval.