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. Author manuscript; available in PMC: 2015 Mar 14.
Published in final edited form as: Circ Res. 2014 Feb 6;114(6):966–975. doi: 10.1161/CIRCRESAHA.114.302364

Figure 5. Expression of cell proliferation markers was increased in the hearts of R2M mice during postnatal growth.

Figure 5

(A) HW/BW of R2M mice at 1, 2, 3 weeks (wk), and 2 months (adult). (B) Left, typical cardiomyocytes from NTG or R2M mouse hearts at 2 weeks. Right, average length and width of cardiomyocytes isolated from 2 week old NTG and R2M hearts. A total of 100–120 cardiomyocytes were counted in each heart, n=3 for each genotype. Scale bar, 20 μm.(C) Representative immunoblot of PCNA in whole heart lysates of NTG and R2M mice at 1, 2 and 3 weeks. (D) mRNA and (E) protein levels of cyclin D1, D2 and E in whole heart lysates of NTG and R2M mice at 2 weeks. n=4; *p< 0.05 versus NTG.