Table 2.
Systemic markers of coagulation*
| Marker | Time | Preconditioning | Control | p value | ||
|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | |||
| Prothrombin fragments F1/F2 | Preoperatively | 252.1 | 244.5 | 344.7 | 217.9 | 0.1827 |
| Tourniquet release | 421.7 | 617.5 | 519.8 | 303.4 | ||
| 3 hours postoperatively | 848.0 | 1176.0 | 954.1 | 1540.7 | ||
| D-dimer | Preoperatively | 693.5 | 306.5 | 574.6 | 300.4 | 0.9749 |
| Tourniquet release | 986.5 | 598.0 | 1027.6 | 551.3 | ||
| 3 hours postoperatively | 8625.3 | 5999.2 | 7481.4 | 6194.2 | ||
| Thrombin-antithrombin complex (TAT) | Preoperatively | 7.3 | 28.0 | 8.4 | 12.6 | 0.2125 |
| Tourniquet release | 35.3 | 86.0 | 22.8 | 28.7 | ||
| 3 hours postoperatively | 69.0 | 66.2 | 59.6 | 74.2 | ||
* All systemic markers of coagulation significantly increased between preoperatively and 3 hours postoperatively (whole cohort: prothrombin fragments F1/F2: p = 0.0011; D-dimer: p < 0.0001; TAT: p = 0.0021). However, there were no differences between the preconditioning and control groups concerning the magnitude of this effect; IQR = interquartile range.