Table 1. Combined ImmunoChip bipolar disorder and primary PGC-BD data.
The SNPs listed are those with a ImmunoChip data P-value < 10−5 which are not covered by the top 34 SNPs in the PGC-BD primary and replication combined study5.
| BD Independent Immunochip data |
PGC-BD Primary data |
ImmunoChip, PGC-BD combined data |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | SNP | Position | A1 | A2 | P-Value | OR | P-Value | OR | P-Value | OR | Gene & Location | |
| 3 | rs9834970 | 36831034 | T | C | 0.0519 | 0.910 | 6.19×10−6 | 0.899 | 3.04×10−6 | 0.901 | LBA | Intergenic |
| 3 | rs3755806 | 52618725 | C | T | 0.0222 | 0.891 | 8.70×10−7 | 0.889 | 4.21×10−7 | 0.889 | PBRM1 | Coding, Syn |
| 12 | rs1006737 | 2215556 | A | G | 4.09×10−4 | 1.198 | 1.73×10−5 | 1.110 | 2.16×10−7 | 1.128 | CACNA1C | Intronic |
| 12 | rs1274726 | 47787665 | C | T | 0.0820 | 1.090 | 1.51×10−6 | 1.130 | 1.48×10−6 | 1.121 | LMBR1L | Intronic |
| 20 | rs2273684 | 32993427 | G | T | 9.23×10−6 | 1.245 | 2.74×10−4 | 1.088 | 4.72×10−7 | 1.119 | GSS | Intronic |
| 20 | rs3818253 | 33060537 | A | G | 2.65×10−6 | 1.333 | 6.18×10−5 | 1.124 | 3.88×10−8 | 1.164 | TRPC4AP | Intronic |
CHR, Chromosome, Position, base pair position according to NCBI Build 36.1; A1, allele 1, odds ratio (OR) is predicted towards allele 1; A2, allele 2; P-value in bold indicates genome-wide statistical significance.