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. 2014 Apr 1;4:4554. doi: 10.1038/srep04554

Figure 2. Febuxostat inhibits plaque formation in ApoE−/− mice.

Figure 2

(a), Representative photographs of en face oil red O staining of aorta (top panels), cross-sectional oil red O staining (middle panels), cross-sectional MOMA-2 staining (middle panels), and cross-sectional hematoxylin-eosin staining (bottom panels) of aortic sinus. Scale bars: 2 mm (top panels) and 200 μm (the other panels). (b), Quantitative analysis of en face oil red O-positive area of aorta from vehicle-treated (n = 10) and febuxostat-treated (n = 10) ApoE−/− mice. Data are shown as mean ± SEM. *P < 0.05 versus vehicle-treated group. (c), Quantitative analysis of cross-sectional oil red O-positive area of aortic sinus from vehicle-treated (n = 19) and febuxostat-treated (n = 19) ApoE−/− mice. Data are pooled from two independent experiments in which similar results were obtained, and shown as mean ± SEM. **P < 0.01 versus vehicle-treated group. (d), Quantitative analysis of cross-sectional MOMA-2-positive area of aortic sinus from vehicle-treated (n = 15) and febuxostat-treated (n = 15) ApoE−/− mice. Data are pooled from two independent experiments in which similar results were obtained, and shown as mean ± SEM.