Figure 4. Febuxostat inhibits the expression of pro-inflammatory genes in the aorta.

qRT-PCR analysis was performed using total RNA extracted from aorta of vehicle-treated WT (n = 10), vehicle-treated (n = 10), and febuxostat-treated (n = 9) ApoE^−/− mice. Data are pooled from two independent experiments in which similar results were obtained, and shown as mean ± SEM. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus vehicle-treated WT mice, *P < 0.05 versus vehicle-treated ApoE^−/− mice.