Figure 2.

The TPI inhibitor PEP and the TPI substrate DHAP have similar interaction sites. (a) Contact distances between TPI and its substrate DHAP, and (b) the interactions of TPI and PEP in the active site. PEP and DHAP are in contact with similar principal residues. Distances are given in Å. Green balls, phosphate; grey balls, carbon; red balls, oxygen. The red circles indicate residues in close proximity to the ligand. Illustrations were prepared using LigPlot. (c) PEP and DHAP bind similarly to the TPI active site. Rabbit TPI bound to PEP, overlaid with the location of the TPI substrate DHAP as determined by Jogl et al. [28] as surface representation. Yellow areas highlight catalytically active residues; PEP: red; DHAP: blue.