Table 1.
Effect of puerarin on mean arterial blood pressure (MAP), blood perfusion, and microvessel diameter in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs).
| Groups | Heart rate | MAP | Blood perfusion | Microvessel diameter (μm) | |
|---|---|---|---|---|---|
| (beat/min) | (mmHg) | (PU) | Arterioles | Venule | |
| WKY | |||||
| Control | 389 ± 21 | 83.72 ± 7.82 | 4.89 ± 1.09 | 42.64 ± 10.43 | 44.72 ± 9.51 |
| Vehicle | 387 ± 12 | 90.73 ± 19.67 | 3.33 ± 0.89 | 44.78 ± 6.04 | 43.66 ± 4.51 |
| Puerarin | 391 ± 28 | 91.51 ± 13.58 | 4.16 ± 0.18 | 47.8 ± 10.91 | 43.78 ± 4.04 |
| SHRs | |||||
| Control | 401 ± 26 | 99.80 ± 16.16* | 4.43 ± 0.77 | 42.82 ± 7.69 | 33.29 ± 8.24 |
| Vehicle | 398 ± 38 | 105.92 ± 22.61 | 3.84 ± 0.82 | 42.84 ± 6.83 | 46.08 ± 15.67 |
| Puerarin | 382 ± 21 | 85.56 ± 15.62# | 3.83 ± 0.89 | 55.20 ± 15.12# | 47.20 ± 15.13 |
| Nimodipine | 378 ± 35 | 113.38 ± 10.10# | 4.76 ± 0.58 | 49.94 ± 12.74# | 41.74 ± 7.09 |
Data are mean ± SD, n = 7. PU: perfusion unit. *P < 0.05 compared with WKY control group; # P < 0.05 compared with SHRs vehicle.