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Bile acid biosynthesis. AKR1D1 associated bile acid deficiency causes accumulation of Δ4- and allo-bile acids and prevents feedback inhibition dependent upon the primary bile acids, cholic acid and chenodeoxycholic acid. CYP7A1, cholesterol 7α-hydroxylase; CYP8B1 sterol 12α-hydroxylase; HSD3B7, 3β-hydroxysteroid dehydrogenase. Enzymes are italicized as their gene names.
