Table 3.
Female SD rat offspring postnatal malformations following in utero exposure of varying dosing period lengths to 520 mg/kg/d of a mixture of 5 PEs (including 40 mg/kg/d DPP and 120 mg/kg/d of each of the following: BBP, DBP, DEHP, and DiBP).
| Dosing period (gestational days; GD) | Control | 8–19 | 8–13 | 14–19 |
| Number of individuals, number of litters | 11,5 | 8,4 | 9,3 | 24,5 |
| Body weight at necropsy (g) | 243.0 ± 5.9 | 230.4 ± 3.8 | 239.5 ± 6.3 | 245.1 ± 4.6 |
| Reproductive malformation (% incidence)a | 0.0 ± 0.0 | 87.5 ± 12.5 b | 22.2 ± 14.6 b | 0.0 ± 0.0 |
| Absent VO (% incidence) | 0.0 ± 0.0 | 75.0 ± 16.4 b | 11.1 ± 11.1 | 0.0 ± 0.0 |
| Uterine agenesis total (% incidence) | 0.0 ± 0.0 | 75.0 ± 16.4 b | 22.2 ± 14.7 | 0.0 ± 0.0 |
| Bilateral (% incidence) | 0.0 ± 0.0 | 50.0 ± 18.9 b | 11.1 ± 11.1 | 0.0 ± 0.0 |
| Unilateral (% incidence) | 0.0 ± 0.0 | 25.0 ± 16.4 b | 11.1 ± 11.1 | 0.0 ± 0.0 |
| Hydrometrocolpos (% incidence) | 0.0 ± 0.0 | 12.5 ± 12.5 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Paired ovarian weight (mg) | 126.9 ± 6.6 | 106.7 ± 12.3 | 131.7 ± 4.3 | 121.6 ± 8.2 |
| Hydronephrosis (% incidence) | 0.0 ± 0.0 | 12.5 ± 12.5 | 22.2 ± 14.6 | 29.2 ± 9.5 b |
| Anopthalmia (% incidence) | 0.0 ± 0.0 | 12.5 ± 12.5 | 11.1 ± 11.1 | 0.0 ± 0.0 |
a
Reproductive malformation = absent VO + uterine agenesis + hydrometrocolpus
b
p < 0.05 versus control (shown in bold).