Figure 1.
Genomic loss (red boxes, top) correlates with broadly decreased gene expression (red boxes, bottom) in the chromosome 6q, 10, and 11q21-ter regions. Each column is data from one melanoma, taken from The Cancer Genome Atlas. The color scale represents log2 data: for DNA it indicates copy number, for RNA it indicates median-centering of expression levels across all samples. Only samples that showed either loss (< −0.5) or retention of two copies (> −0.2, < 0.2) in each region are displayed (n = 135, 140, 150, respectively).