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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Am J Transplant. 2014 Jan 9;14(2):343–355. doi: 10.1111/ajt.12560

Figure 3. Established mixed chimeras accepted VCAs from the original HCT donor between 85 and 150 days later without additional immunosuppression.

Figure 3

Representative clinical images and hematoxylin/eosin stained sections showing complete absence of signs of rejection at day 100 in (A, B) 20311 and (C, D) 20313. A control animal (20312) undergoing conditioning, but not HCT, prior to VCA 100 days later acutely rejected VCA with 9 days with eschar formation (E) and necrosis (F). Two additional control animals (17519, 17520) underwent VCA alone, without conditioning and rejected by day 6 (data not shown). HCT, hematopoietic cell transplantation; VCA, vascularized composite allograft.