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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Am J Transplant. 2014 Jan 9;14(2):343–355. doi: 10.1111/ajt.12560

Figure 5. In vitro evidence of donor-specific unresponsiveness in mixed chimeras prior to VCA transplantation.

Figure 5

(A–C) Mixed lymphocyte reactions (MLRs) were performed 2 and 4 weeks post-HCT, and on an approximately 50-day schedule thereafter. Representative data from 20311 are shown (A) pretransplant, demonstrating normal anti-donor responses, (B) at week 4, and (C) >100 days post-HCT demonstrating specific absence of proliferative response to donor antigen. (D–F) Control animal (20312), which underwent conditioning but did not receive HCT, never demonstrated donor-specific unresponsiveness. CPM, counts per minute; HCT, hematopoietic cell transplantation; VCA, vascularized composite allograft.