Table 2. Significant known risk factors for anthracycline-induced clinical heart failure in children and adolescents (4, e19, e20, e22).
Risk factors | Absolute risk | Relative risk | 95% CI |
---|---|---|---|
Cardiac irradiation | Cardiac irradiation: 27.3% No cardiac irradiation: 2.5% |
11.1 | 3.7 to 33.5 |
Age | <15 years: 1.6% = 15 years: 0.69% |
2.3 | 1.4 to 4 |
Cumulative anthracycline dose | ≥500 mg/m²: 2.4% <500 mg/m²: 0.9% |
2.6 | 1.1 to 6 |
Sex | Female: 1.5% Male: 0.7% |
2.1 | 1.3 to 3.5 |
95% CI: 95% confidence interval