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. 2014 Mar 7;111(10):161–168. doi: 10.3238/arztebl.2014.0161

Table 2. Significant known risk factors for anthracycline-induced clinical heart failure in children and adolescents (4, e19, e20, e22).

Risk factors Absolute risk Relative risk 95% CI
Cardiac irradiation Cardiac irradiation: 27.3%
No cardiac irradiation: 2.5%
11.1 3.7 to 33.5
Age <15 years: 1.6%
= 15 years: 0.69%
2.3 1.4 to 4
Cumulative anthracycline dose ≥500 mg/m²: 2.4%
<500 mg/m²: 0.9%
2.6 1.1 to 6
Sex Female: 1.5%
Male: 0.7%
2.1 1.3 to 3.5

95% CI: 95% confidence interval