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. 2013 Jul 10;1:20. doi: 10.1186/2049-2618-1-20

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Copyright © 2013 Claud et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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16S rRNA-based analysis of samples demonstrates a temporal component to healthy development in preterm infants. Samples from a full term breast-fed infant (solid black squares) cluster distinctly from early stages of preterm infant development (up through five weeks of life) along the first principal axis. Additional clusters are detected along the second principal axis (within two weeks of life (orange triangles), between three to five weeks (green circles) along the second axis) denoting a temporal progression (arrows) of the microbial communities towards a stable healthy state represented by the full term breast-fed infant.