Table 1. Baseline Characteristics Of Study Patients.
| Baseline characteristics | Group A (n = 4) Losartan – spironolactone Mean ± 1 SD | Group B (n = 4) Spironolactone – losartan Mean ± 1 SD | *p-value |
| Age (years) | 64 ± 12 | 63 ± 1 | NS |
| Women/men (%) | 2/2 (50) | 2/2 (50) | NS |
| Systolic BP (mmHg) | 135 ± 19 | 138 ± 22 | NS |
| Diastolic BP (mmHg) | 78 ± 5 | 72 ± 5 | NS |
| Pulse (beats/min) | 64 ± 6 | 62 ± 3 | NS |
| Serum Na (mmol/l) | 137 ± 3 | 138 ± 1 | NS |
| Serum K (mmol/l) | 4.6 ± 0.1 | 4.3 ± 0.1 | NS |
| NYHA class (%) | |||
| II | 2 (50) | 4 (100) | |
| III | 2 (50) | ||
| LVEF (%) | 28 ± 5 | 33 ± 4 | NS |
| Mean heart rate | 82 ± 10 | 68 ± 8 | NS |
| Ventricular ectopics | 346 ± 633 | 1793 ± 706 | NS |
| 24-h SDNN (ms) | 85 ± 39 | 112 ± 34 | NS |
| 24-h SDANN (ms) | 90 ± 47 | 103 ± 28 | NS |
| 24-h RMSSD (ms) | 20 ± 10 | 25 ± 8 | NS |
| 24-h TI | 20 ± 6 | 30 ± 8 | NS |
| QTc dispersion | 69 ± 8 | 70 ± 8 | NS |
| Max QTc | 436 ± 23 | 421 ± 6 | NS |
| Diuretics (mg) | 45 ± 25 | 60 ± 23 | NS |
| ACE inhibitor (mg) | 11 ± 6 | 8 ± 4 | NS |
| Aspirin (mg) | 94 ± 37 | 100 ± 43 | NS |
| Nitrate (mg) | 37 ± 17 | 42 ± 24 | NS |
| Statin (mg) | 17 ± 7 | 16 ± 5 | NS |
NS: not significant, BP: blood presure, LVEF: left ventricular ejection fraction, ACE: angiotensin converting enzyme, statin: HMG-Co reductase inhibitors. *p < 0.05.