Table 3.
Changes of cytokine gene expression in antibiotic treated, Helicobacter hepaticus uninfected mice compared to untreated, uninfected controls
| Vancomycin | One-day recovery from cefoperazone | Six-week recovery from cefoperazone | ||||
|---|---|---|---|---|---|---|
|
Cytokines |
H. hepaticus
uninfected |
SD |
H. hepaticus
uninfected |
SD |
H. hepaticus
uninfected |
SD |
| INFg |
1.13 |
0.66 |
1.64 |
1.31 |
-3.78 |
1.10* |
| IL12a |
1.13 |
0.83 |
8.88 |
0.64* |
-3.58 |
1.10* |
| TNF |
1.28 |
0.21 |
1.56 |
0.27 |
1.64 |
6.12 |
| IL4 |
1.13 |
0.58 |
1.96 |
1.07 |
-1.6 |
1.1 |
| IL13 |
1.60 |
0.21 |
9.25 |
0.83* |
1.51 |
1.1 |
| IL5 |
1.13 |
0.58 |
-21.48 |
1.36* |
-1.6 |
1.1 |
| TGF |
-1.05 |
0.59 |
-51.09 |
1.36* |
-3.29 |
1.40* |
| IL6 |
1.13 |
0.58 |
-21.48 |
1.36* |
-1.6 |
1.1 |
| FOXp3 |
1.13 |
0.58 |
-21.48 |
1.36* |
-1.6 |
1.1 |
| Il17a |
1.68 |
1.16 |
-4.98 |
1.28* |
-1.72 |
1.1 |
| IL23 |
-1.05 |
0.48 |
4.92 |
0.62* |
-1.6 |
1.1 |
| Cxcl2 |
2.26 |
1.15 |
-5.76 |
2.35* |
-1.6 |
1.1 |
| Ccl5 |
-1.01 |
0.66 |
-4.07 |
0.54* |
-5.84 |
7.73* |
| Ccl2 |
3.15 |
0.87* |
9.61 |
0.35* |
-10.2 |
1.10* |
| NOS2 |
2.94 |
1.30 |
-2.23 |
0.03 |
-3.93 |
3.34* |
| ARG1 |
1.13 |
0.58 |
6.41 |
0* |
-1.62 |
0.81 |
| Chi3/4 |
1.13 |
1.19 |
16.45 |
0.26* |
-13.69 |
1.10* |
| PTGS2 |
-1.05 |
0.93 |
1.22 |
0.01 |
2.46 |
4.95 |
| INDO | 1.60 | 0.81 | -26.17 | 0.52* | -2.95 | 1.1 |
Results are presented as mean change. *Statistically significant difference. INF, interferon; IL, interleukin; TNF, tumor necrosis factor; TGF, transforming growth factor; Foxp3, Forkhead box protein 3; NOS, nitric oxide synthase; Chi, chitinase; PTGS, prostaglandin-endoperoxide synthase; INDO, indoleamine-pyrrole 2,3-dioxygenase.