Table 3.
Organ count and results of metabolic cart, breath test, and laboratory studies: treatment group vs control group
| Feda | Fasted | |||||
|---|---|---|---|---|---|---|
| Variable | Time pointb | No. of patients |
Value | No. of patients |
Value | P |
| Organ count, No. (%) | ||||||
| Organs procured | —— | 18 | 4.4 (2.0) | 18 | 4.6 (1.5) | .78 |
| Organs transplanted | —— | 18 | 4.1 (2.1) | 18 | 3.5 (1.8) | .36 |
| Metabolic cart results, mean (SD) | ||||||
| Resting energy expenditure (REE), kcal/d | T1 | 16 | 1773 (778.8) | 17 | 1954 (691.9) | .47c |
| T2 | 18 | 2098 (920.0) | 17 | 1974 (666.1) | .65 | |
| REE predicted, kcal/d | T1 | 16 | 1727 (268.3) | 17 | 1659 (369.3) | .55 |
| T2 | 18 | 1698 (267.1) | 17 | 1659 (369.3) | .72 | |
| REE, kcal/d (values available for both tests) | T1 | 16 | 1773 (778.8) | 17 | 1954 (691.9) | .47c |
| T2 | 16 | 2109 (978.7) | 17 | 1974 (666.1) | .64 | |
| REE predicted, kcal/d (values available for both tests) | T1 | 16 | 1727 (268.3) | 17 | 1659 (369.3) | .55 |
| T2 | 16 | 1727 (268.3) | 17 | 1659 (369.3) | .55 | |
| Timed urine urea nitrogen, mg/dL | T1 | 17 | 297.9 (254.7) | 17 | 444.3 (459.8) | .35c |
| T2 | 17 | 500.9 (468.2) | 18 | 323.1 (296.2) | .16c | |
| Body temperature, °C | T1 | 16 | 36.6 (1.5) | 18 | 37.0 (1.3) | .39 |
| T2 | 16 | 37.1 (1.3) | 15 | 36.8 (0.9) | .44 | |
| Breath test results, mean (SD) | ||||||
| Positive, assimilated | T1 | 18 | 6 (33) | 18 | 4 (22) | .46 |
| T2 | 18 | 5 (28) | 18 | 6 (33) | .72 | |
| Laboratory study results, mean (SD) | ||||||
| Serum albumin, g/dL | T1 | 17 | 3.1 (0.7) | 18 | 2.9 (0.6) | .50 |
| T2 | 16 | 2.7 (0.7) | 14 | 2.7 (0.4) | .85 | |
| ORd | 18 | 2.6 (0.6) | 18 | 2.6 (0.5) | .88 | |
| Prealbumin, mg/dL | T1 | 18 | 16.4 (5.3) | 18 | 16.3 (6.5) | .95 |
| T2 | 18 | 14.0 (3.5) | 18 | 14.2 (5.2) | .87 | |
| C-reactive protein, mg/L | T1 | 18 | 10.8 (9.3) | 18 | 14.2 (10.3) | .31 |
| T2 | 18 | 17.0 (8.0) | 18 | 17.7 (9.7) | .84 | |
| ORd | 18 | 17.3 (8.1) | 18 | 18.3 (8.5) | .72 | |
| Creatinine, mg/dL | T1 | 18 | 2.1 (2.9) | 17 | 1.3 (0.5) | .87c |
| T2 | 16 | 1.4 (0.7) | 16 | 1.2 (0.7) | .52c | |
| ORd | 18 | 2.1 (3.1) | 18 | 1.4 (0.6) | .79c | |
| Alanine aminotransferase, U/L | T1 | 18 | 54.8 (82.9) | 17 | 31.9 (12.8) | .62c |
| T2 | 16 | 67.7 (103.3) | 15 | 37.6 (29.4) | .77c | |
| ORd | 18 | 79.0 (152.2) | 18 | 36.4 (27.5) | .60c | |
| Blood glucose, mg/dL | T1 | 11 | 160.9 (67.5) | 16 | 133.4 (40.5) | .20 |
| T2 | 14 | 176.5 (63.3) | 14 | 170.3 (38.9) | .76 | |
| ORd | 18 | 170.9 (58.5) | 18 | 147.3 (40.8) | .17 | |
| Serum urea nitrogen, mg/dL | ||||||
| T1 | 18 | 21.5 (28.4) | 17 | 14.4 (8.4) | .99c | |
| T2 | 16 | 16.3 (14.9) | 16 | 13.7 (10.7) | .35c | |
| ORc | 18 | 23.8 (27.5) | 18 | 17.4 (12.6) | .57c | |
| Interleukin 6, pg/mL | T1 | 18 | 2162 (3023) | 18 | 1473 (1701) | .74c |
| T2 | 18 | 264.9 (285.6) | 18 | 565.5 (1010) | .48c | |
| ORd | 18 | 283.1 (581.9) | 18 | 522.1 (1022) | .35c | |
| Tumor necrosis factor–α, pg/mL | ||||||
| T1 | 18 | 22.1 (21.0) | 18 | 20.5 (16.1) | .84c | |
| T2 | 18 | 12.6 (9.6) | 18 | 12.6 (9.8) | .61c | |
| ORd | 18 | 12.4 (9.3) | 18 | 13.0 (10.4) | .80c | |
SI conversion factors: To convert albumin and prealbumin to g/L, multiply by 10; to convert C-reactive protein to nmol/L, multiply by 9.524; to convert creatinine to umol/L, multiply by 88.4; to convert alanine aminotransferase to ukat/L, multiply by 0.0167; to convert blood glucose to mmol/L, multiply by 0.0555; to convert serum urea nitrogen to mmol/L, multiply by 0.357.
Patient (HN-06) was randomized to the group with nutritional supplement but failed to receive the intervention.
T1 is before receiving the feeding intervention; T2 is 12 ± 2 hours after baseline; OR is just before transfer to the operating room.
Wilcoxon rank sum test for variables not normally distributed. Fisher’s exact test for variables with small expected cell number. Others: t test for continuous variables and χ2 test for categorical variables. No significant results were found for any variables.
For the patient without values at OR, the last available values were used.