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. 2014 Apr;143(4):465–479. doi: 10.1085/jgp.201311104

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© 2014 Berecki et al.

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Figure 5. — c-Vc1.1 and baclofen inhibit stably expressed Ca_v2.3c calcium channels via G protein–coupled GABA_BRs. Neither compound inhibits I_Ba in the absence of GABA_BRs (see also Fig. 2 C) or the absence of GABA_BR R1 subunits. 1 µM CGP55845 or 500 µM GDP-β-S significantly reduces c-Vc1.1 and baclofen responses, respectively. A 24-h pretreatment with 1 µg/ml PTX abolishes the effect of c-Vc1.1 or baclofen. Data are mean ± SEM (one-way ANOVA; *, P < 0.001 vs. controls; Ca_v2.3/GABA_BR cells with c-Vc1.1 or baclofen, respectively).