Figure 10.

The transport mechanism of exporters (exemplified by the structures of Sav1866₂ and TM287/288) based on the available structures (A) and in schematic representation (B). Coloring is as in Fig. 1. Structures of outward-open and nucleotide-bound inward-facing transporter are shown (Protein Data Bank accession nos. 2HYD and 3QF4; see Table 1 for details of all available structures of ABC transporters). The hydrolysis of ATP in the outward-open conformation results in the reorientation of TMDs, leading to the inward-open conformation where substrate and ATP binding take place. This in turn orients the transporter back into the outward-open conformation, and the substrate is expelled.