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. 2014 Apr;143(4):419–435. doi: 10.1085/jgp.201411164

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© 2014 ter Beek et al.

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Figure 5. — Rearrangements in MBP upon the substrate binding. (A) In the substrate-free form (Protein Data Bank accession no. 1ANF), the cavity between two protein lobes connected by the hinge is accessible. (B) Upon the binding of substrate (dark sticks; Protein Data Bank accession no. 1EZ9), the cavity becomes occluded.