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. 2014 Apr;143(4):499–512. doi: 10.1085/jgp.201311038

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© 2014 Wu et al.

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Figure 2. — Markov modeling of hERG1 tetrameric channel currents modified by drugs PD and ICA. (A) The model comprises seven states (C₀,…,C₄, closed states; O, open state; I, inactivated state) coupled with the indicated rate coefficients. (B) Averaged currents (n = 4) from oocytes expressing WT₄ tetramers under control conditions in response to voltage steps to the indicated V_t. (C) Simulated currents for WT₄ tetramers under control conditions. (D and E) Averaged currents measured from the same oocytes as in B, after application of 30 µM PD (D), and corresponding simulated currents (E). (F and G) Averaged currents (n = 6) measured after application of 30 µM ICA (F) and corresponding simulated currents (G). Currents shown in B, D, and F were not leak subtracted.