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. 2014 Apr;143(4):499–512. doi: 10.1085/jgp.201311038

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© 2014 Wu et al.

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Figure 8. — Concentration- and voltage-dependent effects of ICA on I_test. (A) Concentration-dependent increase in I_test measured at 20 mV by ICA for WT₄ and FL₁/WT₁/FL₂ hERG1 concatenated channels. Data were fitted with a logistic equation (smooth curves). For WT₄ channels: EC₅₀ = 9.1 µM, n_H = 1.7 (n = 6–9); for FL₁/WT₁/FL₂ channels: EC₅₀ = 11.8 µM, n_H = 2.0 (n = 6–10). (B) Fold increase in I_test by 30 µM ICA as a function of V_t (n = 3–8). Data are expressed as mean ± SEM (n = number of oocytes).