Table 2. PSA response to taxane-based treatment.

	BRCA carrier
	Yes, N = 7	No, N = 69	P
Initial response to taxane (n = 76)
Yes (>50% decline)	4 (57%)	28 (42%)	0.5
Yes (31–50% decline)	0 (0%)	14 (20%)
Yes (1–30% decline)	0 (0%)	8 (12%)
No	3 (43%)	19 (28%)
Subgroup with initial response (n = 54)
PSA level at treatment start	44, 1.8, 250, 811*	86 (23, 262)
Lowest PSA level within 12 weeks of treatment start	20, 0.7, 88, 179*	25 (7, 109)
Percentage change in PSA level	−53, −62, −64, −78*	−60 (−78, −35)	0.6

^*Actual values for the four BRCA carriers with an initial response. The median percentage change in PSA level for the four BRCA carriers was −63%.