Table 5.

Maturation index (percentage of superficial and parabasal cells) and vaginal pH: change from baseline to week 12 (last observation carried forward)

	Ospemifene 60 mg/day (n = 363)	Placebo (n = 63)	p Value
	Baseline	Week 12		Change from baseline to week 12	Baseline	Week 12	Change from baseline to week 12
% Superficial cells							< 0.0001
Median (range)	0 (0, 5)	5 (0, 60)	5 (−5, 60.0)	0 (0, 5)	0 (0, 30)	0 (−5, 28)
95% confidence interval			5.0 to 7.0			0.0 to 0.0
% Parabasal cells							< 0.0001
Median (range)	50 (0, 100)	0 (0, 100)	–40 (−100, 75)	48 (0, 100)	70 (0, 100)	0 (−90, 98)
95% confidence interval			−55.0 to −30.0			0.0 to 5.0
Vaginal pH							< 0.0001
Mean ± standard deviation	6.23 ± 0.728	5.03 ± 0.715	–1.21 ± 0.912	6.20 ± 0.749	6.04 ± 0.887	–0.16 ± 0.945