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. 2014 Mar 31;204(7):1219–1236. doi: 10.1083/jcb.201307057

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© 2014 Heller et al.

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Figure 6. — Neuregulin1 and laminin-2 differentially regulate S6rp and NDRG1 phosphorylation. (A) Lysates of P10 nerve from Neuregulin1 type III haploinsufficient or α2-laminin–null (dy^3k/dy^3k) mice were blotted for total and phosphorylated Akt, S6rp, and NDRG1. Whereas p-Akt is reduced in both nerves, phospho-NDRG1 is markedly reduced only in the α2-laminin–null mice. (B) Quantification of the phosphoprotein levels in neuregulin and laminin mutant nerves are shown normalized to total protein in each case. Mean ± SEM; *, P < 0.05; ***, P < 0.001 by two-tailed Student’s t test; n ≥ 3.