Table 2. Inhibition of NA of Influenza Viruses A PR/8/34, J/8178/09, B/55/08, and HK/68 by Compounds Isolated from G. glabra as Determined in CL-Based Enzyme Inhibition Assay.
| 50%
NA inhibitory concentration [μM] against influenza virus Aa |
||||
|---|---|---|---|---|
| code | PR/8/34 | J/8178/09 | B/55/08 | HK/68 |
| 1 | 0.25 ± 0.00 | n.d.b | 1.31 ± 0.00 | n.d.b |
| 2 | 6.47 ± 2.59 | 15.5 ± 5.02 | 30.6 ± 35.2 | 12.4 ± 4.14 |
| 3 | 1.37 ± 0.22 | 3.04 ± 0.88 | 5.04 ± 2.37 | 5.04 ± 1.15 |
| 4 | 0.51 ± 0.00 | 3.00 ± 0.97 | 14.1 ± 18.3 | 3.06 ± 1.21 |
| 5 | 0.40 ± 0.17 | 3.22 ± 1.11 | 9.42 ± 0.42 | 5.34 ± 2.29 |
| 6 | 1.11 ± 0.53 | 2.31 ± 0.23 | 1.20 ± 0.30 | 2.85 ± 1.58 |
| 7 | 2.82 ± 0.36 | 14.7 ± 3.71 | n.d.b | 9.18 ± 3.73 |
| 8 | 0.04 ± 0.02 | n.d.b | 2.83 ± 1.12 | n.d.b |
| 9 | 0.34 ± 0.17 | n.d.b | 4.52 ± 2.34 | n.d.b |
| 10 | 2.07 ± 0.37 | n.d.b | 8.33 ± 3.03 | n.d.b |
| 11 | 83.1 ± 17.8 | n.d.b | 140 ± 12.8 | n.d.b |
| 12 | 3.00 ± 0.46 | n.d.b | 4.53 ± 1.85 | n.d.b |
| oseltamivir | 0.0003 ± 0.0001 | 0.0005 ± 0.0002 | 0.08 ± 0.02 | 0.0002 ± 0.0001 |
a
n = 3, each concentration in duplicate.
b
Not determined.