Table 3. Cytotoxicity and Inhibition of the Cytopathic Effect (CPE) by Compounds Isolated from G. glabra as Determined in MDCK Cells.
50%
CPE inhibitory concentration [μM]a |
|||
---|---|---|---|
code | J/8178/09 | HK/68 | 50% cytotoxic concentration [μM]b |
1 | 29.7%c | 48.1%c | 135 ± 36.3 |
2 | 36.1%c | n.a.d | 336 ± 38.4 |
3 | 38.2 ± 4.79 | 42.6 ± 0.49 | 123 ± 48.3 |
4 | n.a.d | n.a.d | 25.4 ± 2.58 |
5 | 34.7 ± 14.8 | 24.2%c | 90.8 ± 34.9 |
6 | 48.4%c | 31.2%c | 39.2 ± 15.9 |
7 | 34.2%c | n.a.d | 79.7 ± 29.9 |
8 | n.a.d | n.a.d | >144 |
9 | n.a.d | n.a.d | >144 |
10 | n.a.d | n.a.d | 301 ± 25.5 |
11 | n.a.d | n.a.d | >239 |
12 | 49.6%c | n.a.d | 126 ± 34.5 |
oseltamivir | 0.03 ± 0.01 | 0.004 ± 0.002 | n.d.e |
n = 2 to 3, each concentration once.
n = 3, each concentration in triplicate.
Percentage of maximal inhibition of the CPE at a concentration of 50 μM.
Not active (up to 50 μM).
Not determined.