Figure 4.

Total number of BrdU⁺ cells and BrdU⁺/NeuN⁺ cells per mm² in the dentate subgranular zone of the Juvenile-RCI cohort. (a) In the contralateral hemisphere, there was a no significant group difference for BrdU⁺ cells (p = 0.242) or BrdU⁺/NeuN⁺ (p = 0.697). Percentage change compared with sham-treated animals. (b) In the ipsilateral hemisphere, there was a significant group difference for BrdU⁺ cells (p = 0.006) and BrdU⁺/NeuN⁺ (p = 0.004). RCI significantly increased the numbers of BrdU⁺ cells and BrdU⁺/NeuN⁺ compared to sham-treated and radiation only (p < 0.05). Percentage change compared with sham-treated animals. Each bar represents the mean of 9–10 mice; error bars are standard error of the mean (SEM).