Table 3.
Age groups, years |
Overall p value | ||||
---|---|---|---|---|---|
< 60 | 60–64 | > 64 | Total | ||
Fatigue grade 3+4* | |||||
Treatment, % (n) | |||||
TAC | 11.6 (175) | 12.7 (34) | 17.1 (29) | 12.2 (238) | 0.113 |
Canadian FE120C | – | – | – | – | – |
A(E)C-[T/P] | 8.5 (28) | 11.8 (8) | 16.0 (8) | 44 (9.8) | 0.208 |
ddAT | 24.7 (81) | 39.5 (32) | 35.0 (14) | 28.3 (127) | 0.018 |
ddE-ddP | – | – | – | – | – |
Stomatitis grade 3+4* | |||||
Treatment, % (n) | |||||
TAC | 3.6 (54) | 3.7 (10) | 5.9 (10) | 3.8 (74) | 0.328 |
Canadian FE120C | 6.8 (24) | 9.3 (10) | 14.5 (12) | 8.4 (46) | 0.073 |
A(E)C-[T/P] | 1.2 (12) | 0.4 (1) | 2.4 (4) | 1.2 (17) | 0.203 |
ddAT | 2.8 (9) | 7.4 (6) | 5.0 (2) | 3.8 (17) | 0.133 |
ddE-ddP | 2.1 (6) | 13.2 (7) | 11.9 (5) | 4.8 (18) | < 0.001 |
Diarrhea grade 3+4* | |||||
Treatment, % (n) | |||||
TAC | 3.5 (53) | 3.4 (9) | 8.2 (14) | 3.9 (76) | 0.010 |
Canadian FE120C | 1.4 (5) | 3.7 (4) | 2.4 (2) | 2.0 (11) | 0.321 |
A(E)C-[T/P] | 0.4 (4) | 0.0 (0) | 0.0 (0) | 0.3 (4) | 0.446 |
ddAT | 8.3 (27) | 7.4 (6) | 2.5 (1) | 7.6 (34) | 0.430 |
ddE-ddP | 0.7 (2) | 0.0 (0) | 0.0 (0) | 0.5 (2) | 0.711 |
Sensory neuropathy grade 3+4* | |||||
Treatment, % (n) | |||||
TAC | 1.1 (17) | 2.2 (6) | 1.8 (3) | 1.3 (26) | 0.303 |
Canadian FE120C | 0.6 (2) | 0.0 (0) | 0.0 (0) | 0.4 (2) | 0.581 |
A(E)C-[T/P] | 0.1 (1) | 0.0 (0) | 0.0 (0) | 0.1 (1) | 0.817 |
ddAT | 0.9 (3) | 2.5 (2) | 0.0 (0) | 1.1 (5) | 0.384 |
ddE-ddP | 0.0 (0) | 0.0 (0) | 0.0 (0) | 0.0 (0) | – |
Increase of liver enzymes grade 3+4 | |||||
Treatment, % (n) | |||||
TAC | 2.3 (34) | 2.3 (5) | 2.0 (3) | 2.2 (42) | 0.981 |
Canadian FE120C | 2.1 (7) | 1.9 (2) | 2.5 (2) | 2.1 (11) | 0.960 |
A(E)C-[T/P] | 2.1 (20) | 2.3 (5) | 0.0 (0) | 1.9 (25) | 0.183 |
ddAT | 1.8 (6) | 5.0 (4) | 7.5 (3) | 2.9 (13) | 0.064 |
ddE-ddP | 10.3 (28) | 3.8 (2) | 0.0 (0) | 8.3 (30) | 0.050 |
Increase of creatinine grade 3+4* | |||||
Treatment, % (n) | |||||
TAC | 4.5 (68) | 9.3 (25) | 9.5 (16) | 5.6 (109) | < 0.001 |
Canadian FE120C | – | – | – | – | – |
A(E)C-[T/P] | 0.5 (3) | 2.4 (3) | 1.2 (1) | 0.9 (7) | 0.124 |
ddAT | 1.2 (4) | 1.3 (1) | 2.5 (1) | 1.4 (6) | 0.804 |
ddE-ddP | 0.0 (0) | 3.7 (2) | 8.6 (3) | 1.4 (5) | < 0.001 |
F = 5-fluouracil
A: adriamycin
E = epirubicin
C = cyclophosphamide
T = docetaxel
P = paclitaxel
dd = dose dense.
According to the National Cancer Institute Common Terminology Criteria (Version 3 Terminology).