Table 1.
Association analysis results for the two image-based biomarkers (phenotypes) and the genomic biomarkers (genotypes) from Pearson correlation analysis (both unadjusted and corrected p-values are listed). *Corrected p-values from permutation for correction for multiple testing. *SNP positions are based on the human reference sequence (NCBI Build 36.1).
| Quantile-normalized Image-based biomarkers (Phenotypes) |
||||||
|---|---|---|---|---|---|---|
| Image characteristic | Mathematical descriptors | Genomic biomarkers (SNPs) (SNP position in Chr4*) | p-value | p-value after correction* | Relative position | Correlation with expression |
| Texture | MaxEdgeGradient | 69630002 | 0.00026 | 0.022 | 86.3kb upstream of | UGT2B17 |
| (Ref. 18) | (rs451632) | UGT2B10, 59.0kb | in liver | |||
| downstream of UGT2B15 | ||||||
| Texture | β (Power law) | 70499290 | 0.00044 | 0.035 | 103.1kb | UGT2B7 |
| and | (Ref. 31) | (rs4148298) | downstream | in liver | ||
| density | of UGT2B4 | |||||