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PHB expression restored spatial working memory loss following BCCAO in mice. (A) Total number of arm entry in 8 min Y-maze tests before and 7 day after BCCAO. An increase in motor activity after BCCAO was observed, but the difference between vector and PHB injected mice was non-significant (n.s.). (B) Y-maze arm entry alteration test for PHB and vector injected mice before and 7 days after BCCAO. PHB expression prevented the decrease in arm entry alternations. *p<0.05, n=8 /group.
