Table 2.
Associations between DUSP genes, diet and colon and rectal cancer risk
|
|
Pint | Padj | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | Intermediate | High | ||||||||||||
|
| ||||||||||||||
| Control | Case | OR1 | 95% CI | Control | Case | OR | 95% CI | Control | Case | OR | (95% CI) | |||
|
|
||||||||||||||
| Colon Cancer | ||||||||||||||
| Carbohydrates | ||||||||||||||
| DUSP2 (rs1724120) | 0.01 | 0.01 | ||||||||||||
| GG/GA | 380 | 311 | 1.00 | 793 | 592 | 0.82 | (0.67, 1.00) | 392 | 305 | 0.69 | (0.51, 0.92) | |||
| AA | 109 | 71 | 0.79 | (0.56, 1.10) | 187 | 169 | 1.00 | (0.76, 1.30) | 95 | 107 | 0.98 | (0.67, 1.43) | ||
| Mutagen Index | ||||||||||||||
| DUSP6 (rs770087)2 | 0.03 | 0.03 | ||||||||||||
| TT | 349 | 223 | 1.00 | 607 | 467 | 1.18 | (0.96, 1.45) | 288 | 285 | 1.50 | (1.19, 1.91) | |||
| TG/GG | 158 | 132 | 1.29 | (0.96, 1.71) | 361 | 288 | 1.23 | (0.98, 1.54) | 192 | 160 | 1.24 | (0.94, 1.63) | ||
| Rectal Cancer | ||||||||||||||
| Energy Intake | ||||||||||||||
| DUSP6 (rs10744) 3 | 0.02 | 0.02 | ||||||||||||
| AA | 142 | 124 | 1.00 | 304 | 230 | 0.86 | (0.64, 1.17) | 152 | 136 | 1.00 | (0.71, 1.41) | |||
| AT/TT | 104 | 55 | 0.60 | (0.40, 0.90) | 168 | 116 | 0.78 | (0.55, 1.09) | 88 | 93 | 1.16 | (0.79, 1.71) | ||
| Monounsaturated Fat | ||||||||||||||
| DUSP4 (rs2056025) | 0.01 | 0.03 | ||||||||||||
| TT | 169 | 144 | 1.00 | 353 | 260 | 0.79 | (0.59, 1.06) | 186 | 156 | 0.75 | (0.49, 1.15) | |||
| TG | 67 | 38 | 0.65 | (0.41, 1.02) | 113 | 93 | 0.88 | (0.61, 1.27) | 52 | 54 | 0.91 | (0.53, 1.55) | ||
| GG | 8 | 1 | 0.14 | (<0.01, 0.80) | 9 | 5 | 0.60 | (0.18, 1.80) | 2 | 3 | 1.20 | (0.19, 9.48) | ||
| DUSP4 (rs474824) | 0.01 | 0.03 | ||||||||||||
| TT | 82 | 72 | 1.00 | 171 | 125 | 0.76 | (0.51, 1.15) | 90 | 61 | 0.60 | (0.35, 1.04) | |||
| TC | 104 | 87 | 0.93 | (0.61, 1.43) | 231 | 167 | 0.75 | (0.51, 1.10) | 102 | 107 | 0.90 | (0.54, 1.51) | ||
| CC | 58 | 24 | 0.43 | (0.24, 0.77) | 73 | 66 | 0.90 | (0.56, 1.44) | 48 | 45 | 0.77 | (0.42, 1.40) | ||
| Polyunsaturated Fat | ||||||||||||||
| DUSP4 (rs2056025) | 0.01 | 0.03 | ||||||||||||
| TT | 168 | 139 | 1.00 | 353 | 260 | 0.83 | (0.62, 1.12) | 187 | 161 | 0.86 | (0.57, 1.30) | |||
| TG | 69 | 33 | 0.56 | (0.35, 0.90) | 110 | 97 | 0.99 | (0.68, 1.43) | 53 | 55 | 1.02 | (0.60, 1.71) | ||
| GG | 9 | 2 | 0.27 | (0.04, 1.06) | 8 | 4 | 0.56 | (0.15, 1.82) | 2 | 3 | 1.35 | (0.21, 10.66) | ||
| Trans-Fatty Acid | ||||||||||||||
| DUSP4 (rs474824) | 0.01 | 0.03 | ||||||||||||
| TT | 87 | 75 | 1.00 | 163 | 112 | 0.79 | (0.53, 1.19) | 93 | 71 | 0.84 | (0.51, 1.37) | |||
| TC | 109 | 78 | 0.82 | (0.54, 1.26) | 223 | 169 | 0.86 | (0.59, 1.25) | 105 | 114 | 1.17 | (0.73, 1.87) | ||
| CC | 52 | 25 | 0.52 | (0.29, 0.91) | 85 | 61 | 0.78 | (0.49, 1.24) | 42 | 49 | 1.18 | (0.67, 2.09) | ||
| Folic Acid | ||||||||||||||
| DUSP4 (rs2056025) | 0.01 | 0.04 | ||||||||||||
| TT/TG | 237 | 208 | 1.00 | 467 | 353 | 0.73 | (0.57, 0.94) | 236 | 184 | 0.57 | (0.39, 0.82) | |||
| GG | 10 | 1 | 0.11 | (<0.01, 0.60) | 7 | 4 | 0.56 | (0.14, 1.88) | 2 | 4 | 1.39 | (0.26, 10.38) | ||
| Calcium | ||||||||||||||
| DUSP6 (rs10744) 3 | <0.01 | <0.01 | ||||||||||||
| AA | 131 | 138 | 1.00 | 314 | 250 | 0.65 | (0.48, 0.88) | 153 | 102 | 0.44 | (0.29, 0.67) | |||
| AT/TT | 111 | 64 | 0.54 | (0.36, 0.79) | 164 | 120 | 0.59 | (0.42, 0.84) | 85 | 80 | 0.59 | (0.37, 0.93) | ||
| Vitamin D | ||||||||||||||
| DUSP4 (rs474824) | 0.01 | 0.03 | ||||||||||||
| TT | 81 | 78 | 1.00 | 164 | 119 | 0.70 | (0.47, 1.04) | 98 | 61 | 0.52 | (0.32, 0.84) | |||
| TC | 106 | 84 | 0.80 | (0.52, 1.22) | 225 | 188 | 0.79 | (0.54, 1.15) | 106 | 89 | 0.68 | (0.43, 1.08) | ||
| CC | 56 | 31 | 0.53 | (0.30, 0.91) | 90 | 72 | 0.71 | (0.45, 1.12) | 33 | 32 | 0.76 | (0.41, 1.40) | ||
| DUSP6 (rs10744) 3 | 0.01 | 0.01 | ||||||||||||
| AA | 143 | 133 | 1.00 | 302 | 255 | 0.85 | (0.63, 1.15) | 153 | 102 | 0.59 | (0.40, 0.87) | |||
| AT/TT | 99 | 60 | 0.66 | (0.44, 0.98) | 177 | 124 | 0.70 | (0.50, 0.98) | 84 | 80 | 0.81 | (0.52, 1.25) | ||
| DUSP7 (rs9851576) | <0.01 | <0.01 | ||||||||||||
| AA/AG | 239 | 183 | 1.00 | 457 | 362 | 0.95 | (0.74, 1.23) | 224 | 179 | 0.83 | (0.59, 1.16) | |||
| GG | 3 | 10 | 4.17 | (1.24, 18.9) | 22 | 17 | 0.90 | (0.46, 1.76) | 13 | 3 | 0.21 | (0.05, 0.70) | ||
| Selenium | ||||||||||||||
| DUSP4 (rs2056025) | 0.01 | 0.03 | ||||||||||||
| TT | 175 | 147 | 1.00 | 344 | 258 | 0.80 | (0.60, 1.07) | 189 | 155 | 0.77 | (0.52, 1.14) | |||
| TG/GG | 68 | 36 | 0.62 | (0.39, 0.97) | 132 | 97 | 0.78 | (0.54, 1.11) | 51 | 61 | 1.10 | (0.67, 1.82) | ||
| Lycopene | ||||||||||||||
| DUSP1 (rs881150) | 0.01 | 0.02 | ||||||||||||
| TT | 128 | 132 | 1.00 | 269 | 217 | 0.69 | (0.51, 0.95) | 139 | 102 | 0.54 | (0.37, 0.81) | |||
| TA/AA | 115 | 71 | 0.61 | (0.41, 0.89) | 206 | 142 | 0.61 | (0.43, 0.85) | 102 | 90 | 0.67 | (0.44, 1.00) | ||
| DUSP6 (rs10744) | 0.02 | 0.03 | ||||||||||||
| AA | 149 | 147 | 1.00 | 300 | 232 | 0.69 | (0.51, 0.93) | 149 | 111 | 0.59 | (0.41, 0.86) | |||
| AT/TT | 94 | 56 | 0.60 | (0.40, 0.89) | 175 | 127 | 0.66 | (0.47, 0.92) | 91 | 81 | 0.67 | (0.44, 1.02) | ||
| Mutagen Index | ||||||||||||||
| DUSP4 (rs474824) | <0.01 | 0.02 | ||||||||||||
| TT/TC | 193 | 142 | 1.00 | 388 | 324 | 1.10 | (0.84, 1.43) | 199 | 153 | 0.98 | (0.72, 1.34) | |||
| CC | 47 | 23 | 0.62 | (0.35, 1.06) | 93 | 60 | 0.80 | (0.54, 1.19) | 39 | 52 | 1.61 | (1.00, 2.61) | ||
1
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, center, race, sex, and kcal. Percentiles based on sex and study.
2
Similar associations for DUSP6 rs10744 (r2=1)
3
Similar associations for DUSP6 rs770087 (r2=1)