Table 4.
Association between JNK-pathway genes, diet, and colon and rectal cancer
| Low | Intermediate | High | Pint | Padj | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Control | Case | OR1 | 95% CI | Control | Case | OR | 95% CI | Control | Case | OR | 95% CI | |||
|
|
||||||||||||||
| Colon Cancer | ||||||||||||||
| Protein | ||||||||||||||
| MAP3K7 (rs13208824) | 0.01 | 0.03 | ||||||||||||
| CC/CA | 479 | 342 | 1.00 | 950 | 771 | 1.05 | (0.87, 1.26) | 490 | 415 | 0.92 | (0.69, 1.22) | |||
| AA | 10 | 3 | 0.42 | (0.09, 1.39) | 24 | 14 | 0.75 | (0.37, 1.47) | 3 | 10 | 3.97 | (1.18, 18.03) | ||
| Vitamin C | ||||||||||||||
| MAP3K7 (rs150117) | <0.01 | 0.01 | ||||||||||||
| AA | 216 | 197 | 1.00 | 458 | 363 | 0.85 | (0.67, 1.08) | 252 | 176 | 0.67 | (0.50, 0.89) | |||
| AT | 217 | 145 | 0.74 | (0.56, 0.99) | 400 | 368 | 0.97 | (0.76, 1.23) | 192 | 156 | 0.78 | (0.58, 1.05) | ||
| TT | 56 | 37 | 0.73 | (0.46, 1.16) | 123 | 61 | 0.53 | (0.37, 0.76) | 42 | 51 | 1.16 | (0.73, 1.85) | ||
| Folic Acid | ||||||||||||||
| MAP3K10 (rs3746006) | 0.02 | 0.04 | ||||||||||||
| GG/GA | 431 | 368 | 1.00 | 886 | 699 | 0.82 | (0.69, 0.99) | 445 | 340 | 0.66 | (0.52, 0.84) | |||
| AA | 57 | 33 | 0.69 | (0.44, 1.08) | 95 | 72 | 0.80 | (0.57, 1.13) | 38 | 42 | 1.00 | (0.62, 1.62) | ||
| MAP3K7 (rs150117) | 0.01 | 0.03 | ||||||||||||
| AA | 207 | 187 | 1.00 | 485 | 390 | 0.79 | (0.62, 1.01) | 234 | 159 | 0.54 | (0.40, 0.75) | |||
| AT | 222 | 176 | 0.87 | (0.66, 1.16) | 387 | 322 | 0.81 | (0.63, 1.05) | 200 | 171 | 0.70 | (0.51, 0.96) | ||
| TT | 59 | 38 | 0.71 | (0.45, 1.11) | 113 | 59 | 0.52 | (0.35, 0.75) | 49 | 52 | 0.89 | (0.56, 1.40) | ||
| Calcium | ||||||||||||||
| MAPK8 (rs10857565) | 0.02 | 0.04 | ||||||||||||
| GG/GA | 471 | 385 | 1.00 | 935 | 737 | 0.86 | (0.72, 1.03) | 464 | 351 | 0.70 | (0.55, 0.89) | |||
| AA | 15 | 24 | 2.06 | (1.07, 4.07) | 44 | 43 | 1.11 | (0.70, 1.73) | 27 | 15 | 0.48 | (0.24, 0.93) | ||
| Lutein + Zeaxanthin | ||||||||||||||
| MAP3K9 (rs11158881) | <0.01 | 0.03 | ||||||||||||
| TT | 284 | 225 | 1.00 | 553 | 441 | 0.91 | (0.73, 1.14) | 256 | 240 | 0.92 | (0.70, 1.20) | |||
| TC/CC | 207 | 194 | 1.19 | (0.92, 1.55) | 432 | 310 | 0.83 | (0.65, 1.04) | 224 | 144 | 0.62 | (0.46, 0.83) | ||
| MAP3K9 (rs11622989) | <0.01 | 0.03 | ||||||||||||
| CC/CT | 377 | 302 | 1.00 | 747 | 563 | 0.85 | (0.70, 1.03) | 353 | 313 | 0.85 | (0.67, 1.08) | |||
| TT | 114 | 117 | 1.28 | (0.95, 1.73) | 237 | 187 | 0.90 | (0.70, 1.15) | 127 | 71 | 0.56 | (0.40, 0.78) | ||
| MAP3K9 (rs11624934) | 0.01 | 0.04 | ||||||||||||
| AA | 224 | 213 | 1.00 | 471 | 343 | 0.70 | (0.55, 0.89) | 230 | 160 | 0.57 | (0.43, 0.77) | |||
| AG | 222 | 170 | 0.81 | (0.61, 1.07) | 434 | 324 | 0.71 | (0.56, 0.91) | 216 | 174 | 0.65 | (0.49, 0.87) | ||
| GG | 45 | 36 | 0.87 | (0.54, 1.41) | 79 | 84 | 1.04 | (0.72, 1.50) | 34 | 51 | 1.21 | (0.75, 1.98) | ||
| MAP3K9 (rs11625206) | <0.01 | 0.01 | ||||||||||||
| CC | 210 | 213 | 1.00 | 452 | 330 | 0.66 | (0.51, 0.84) | 232 | 155 | 0.51 | (0.38, 0.69) | |||
| CT | 230 | 166 | 0.72 | (0.55, 0.95) | 448 | 323 | 0.65 | (0.51, 0.83) | 205 | 177 | 0.66 | (0.49, 0.89) | ||
| TT | 51 | 40 | 0.81 | (0.51, 1.27) | 84 | 98 | 1.08 | (0.76, 1.54) | 43 | 51 | 0.92 | (0.58, 1.46) | ||
| MAP3K9 (rs11844774) 2 | <0.01 | 0.01 | ||||||||||||
| TT | 163 | 128 | 1.00 | 320 | 281 | 1.01 | (0.76, 1.35) | 143 | 154 | 1.07 | (0.76, 1.50) | |||
| TC | 243 | 207 | 1.08 | (0.80, 1.45) | 474 | 338 | 0.82 | (0.62, 1.08) | 236 | 170 | 0.69 | (0.50, 0.96) | ||
| CC | 85 | 84 | 1.27 | (0.87, 1.86) | 190 | 132 | 0.79 | (0.57, 1.10) | 101 | 60 | 0.57 | (0.38, 0.86) | ||
| Rectal Cancer | ||||||||||||||
| Carbohydrates | ||||||||||||||
| MAP3K7 (rs3799912) | <0.01 | 0.02 | ||||||||||||
| AA | 191 | 169 | 1.00 | 376 | 293 | 0.71 | (0.53, 0.94) | 195 | 140 | 0.44 | (0.28, 0.68) | |||
| AG/GG | 55 | 34 | 0.70 | (0.43, 1.12) | 98 | 64 | 0.60 | (0.40, 0.89) | 44 | 54 | 0.80 | (0.47, 1.38) | ||
| Calcium | ||||||||||||||
| MAP3K3 (rs3785574) | 0.02 | 0.05 | ||||||||||||
| AA/AG | 225 | 177 | 1.00 | 424 | 322 | 0.83 | (0.64, 1.08) | 213 | 171 | 0.69 | (0.48, 1.00) | |||
| GG | 17 | 25 | 1.87 | (0.99, 3.64) | 55 | 48 | 0.92 | (0.59, 1.45) | 25 | 11 | 0.40 | (0.18, 0.84) | ||
| Lutein + Zeaxanthin | ||||||||||||||
| MAP3K3 (rs11658329) | 0.01 | 0.02 | ||||||||||||
| GG/GC | 232 | 173 | 1.00 | 430 | 345 | 0.96 | (0.75, 1.24) | 210 | 176 | 0.88 | (0.63, 1.21) | |||
| CC | 13 | 17 | 1.72 | (0.81, 3.70) | 44 | 32 | 0.83 | (0.50, 1.38) | 30 | 11 | 0.38 | (0.17, 0.77) | ||
| Cruciferous Vegetables | ||||||||||||||
| MAP3K1 (rs43184) 3 | 0.01 | 0.04 | ||||||||||||
| CC | 142 | 124 | 1.00 | 295 | 246 | 0.94 | (0.70, 1.26) | 161 | 113 | 0.75 | (0.53, 1.06) | |||
| CG | 83 | 43 | 0.59 | (0.38, 0.92) | 163 | 129 | 0.86 | (0.61, 1.21) | 69 | 59 | 0.87 | (0.56, 1.35) | ||
| GG | 11 | 7 | 0.73 | (0.26, 1.91) | 28 | 22 | 0.86 | (0.46, 1.57) | 7 | 11 | 1.71 | (0.65, 4.79) | ||
| MAP3K7 (rs3799912) | <0.01 | <0.01 | ||||||||||||
| AA | 186 | 151 | 1.00 | 386 | 324 | 1.00 | (0.77, 1.30) | 190 | 127 | 0.75 | (0.54, 1.03) | |||
| AG/GG | 50 | 23 | 0.56 | (0.32, 0.96) | 100 | 73 | 0.88 | (0.60, 1.27) | 47 | 56 | 1.38 | (0.88, 2.17) | ||
| MAP3K7 (rs711267) | <0.01 | 0.01 | ||||||||||||
| AA/AG | 224 | 153 | 1.00 | 447 | 369 | 1.18 | (0.92, 1.51) | 211 | 172 | 1.10 | (0.82, 1.48) | |||
| GG | 12 | 21 | 2.74 | (1.32, 5.92) | 39 | 28 | 1.02 | (0.60, 1.73) | 26 | 11 | 0.58 | (0.27, 1.18) | ||
1
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, center, race, sex, and kcal. Percentiles based on sex and study.
2
Similar associations for MAP3K9 rs8010714 (r2=0.99)
3
Similar associations for MAP3K1 rs832582 (r2=1)