Table 5.
Associations between p38-pathway genes, diet, and colon and rectal cancer risk
| Low | Intermediate | High | Pint | Padj | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Control | Case | OR1 | 95% CI | Control | Case | OR | 95% CI | Control | Case | OR | (95% CI) | |||
|
|
||||||||||||||
| Colon Cancer | ||||||||||||||
| Energy Intake | ||||||||||||||
| MAPK14 (rs10807156) | 0.01 | 0.04 | ||||||||||||
| TT | 314 | 207 | 1.00 | 620 | 483 | 1.17 | (0.95, 1.45) | 288 | 302 | 1.55 | (1.21, 1.97) | |||
| TA | 149 | 109 | 1.09 | (0.80, 1.48) | 325 | 256 | 1.18 | (0.93, 1.51) | 164 | 134 | 1.21 | (0.91, 1.62) | ||
| AA | 21 | 20 | 1.46 | (0.76, 2.77) | 39 | 28 | 1.08 | (0.64, 1.80) | 32 | 14 | 0.65 | (0.33, 1.23) | ||
| Carbohydrate | ||||||||||||||
| MAP3K2 (rs6732279) | 0.01 | 0.03 | ||||||||||||
| GG | 217 | 146 | 1.00 | 377 | 288 | 1.02 | (0.78, 1.34) | 175 | 171 | 1.06 | (0.73, 1.52) | |||
| GT | 222 | 185 | 1.25 | (0.94, 1.67) | 462 | 362 | 1.06 | (0.81, 1.37) | 243 | 183 | 0.82 | (0.57, 1.17) | ||
| TT | 49 | 51 | 1.57 | (1.01, 2.46) | 141 | 111 | 1.07 | (0.76, 1.49) | 69 | 58 | 0.87 | (0.55, 1.38) | ||
| MAPK14 (rs10807156) | 0.01 | 0.04 | ||||||||||||
| TT | 318 | 229 | 1.00 | 615 | 497 | 1.01 | (0.81, 1.26) | 289 | 266 | 0.93 | (0.67, 1.28) | |||
| TA | 146 | 128 | 1.20 | (0.90, 1.61) | 326 | 237 | 0.91 | (0.71, 1.17) | 166 | 134 | 0.83 | (0.58, 1.18) | ||
| AA | 23 | 25 | 1.53 | (0.85, 2.79) | 38 | 26 | 0.85 | (0.49, 1.44) | 31 | 11 | 0.37 | (0.17, 0.74) | ||
| Folic Acid | ||||||||||||||
| MAP3K2 (rs6732279) | 0.01 | 0.03 | ||||||||||||
| GG | 214 | 161 | 1.00 | 391 | 284 | 0.85 | (0.65, 1.11) | 164 | 160 | 0.96 | (0.69, 1.34) | |||
| GT | 220 | 187 | 1.13 | (0.85, 1.51) | 459 | 366 | 0.95 | (0.74, 1.23) | 248 | 177 | 0.71 | (0.52, 0.97) | ||
| TT | 54 | 53 | 1.30 | (0.84, 2.00) | 134 | 121 | 1.07 | (0.77, 1.49) | 71 | 46 | 0.62 | (0.39, 0.96) | ||
| Rectal Cancer | ||||||||||||||
| Saturated Fat | ||||||||||||||
| MAPK14 (rs851011)2 | <0.01 | 0.02 | ||||||||||||
| TT/TC | 242 | 166 | 1.00 | 472 | 359 | 1.06 | (0.82, 1.38) | 227 | 218 | 1.23 | (0.83, 1.82) | |||
| CC | 3 | 6 | 3.12 | (0.81, 14.99) | 7 | 4 | 0.86 | (0.22, 2.90) | 8 | 1 | 0.15 | (<0.01, 0.87) | ||
| Calcium | ||||||||||||||
| MAPK12 (rs742184) | 0.02 | 0.04 | ||||||||||||
| CC | 125 | 119 | 1.00 | 239 | 191 | 0.72 | (0.52, 1.01) | 138 | 90 | 0.46 | (0.29, 0.71) | |||
| CT/TT | 117 | 83 | 0.75 | (0.51, 1.09) | 240 | 179 | 0.67 | (0.48, 0.93) | 100 | 92 | 0.66 | (0.43, 1.02) | ||
| Vitamin C | ||||||||||||||
| MAPK14 (rs851006) | <0.01 | 0.02 | ||||||||||||
| GG | 139 | 132 | 1.00 | 270 | 221 | 0.81 | (0.59, 1.09) | 156 | 99 | 0.55 | (0.38, 0.80) | |||
| GA | 91 | 70 | 0.82 | (0.55, 1.21) | 178 | 109 | 0.60 | (0.43, 0.85) | 69 | 77 | 0.97 | (0.63, 1.50) | ||
| AA | 13 | 8 | 0.67 | (0.26, 1.65) | 30 | 21 | 0.70 | (0.38, 1.29) | 13 | 17 | 1.17 | (0.54, 2.58) | ||
| Selenium | ||||||||||||||
| MAPK14 (rs851011)2 | <0.01 | 0.02 | ||||||||||||
| TT/TC | 242 | 177 | 1.00 | 467 | 352 | 0.92 | (0.71, 1.20) | 232 | 214 | 0.99 | (0.69, 1.44) | |||
| CC | 1 | 6 | 8.97 | (1.51, 170.50) | 9 | 3 | 0.43 | (0.09, 1.48) | 8 | 2 | 0.25 | (0.04, 1.07) | ||
| Lycopene | ||||||||||||||
| MAP3K2 (rs3732209) | 0.01 | 0.03 | ||||||||||||
| TT | 126 | 114 | 1.00 | 233 | 188 | 0.78 | (0.56, 1.08) | 128 | 84 | 0.55 | (0.36, 0.83) | |||
| TC | 93 | 77 | 0.91 | (0.61, 1.35) | 193 | 144 | 0.74 | (0.53, 1.05) | 95 | 86 | 0.78 | (0.51, 1.19) | ||
| CC | 24 | 12 | 0.57 | (0.27, 1.18) | 49 | 27 | 0.56 | (0.32, 0.96) | 18 | 22 | 1.03 | (0.51, 2.09) | ||
| Alpha-tocopherol | ||||||||||||||
| MAP2K1 (rs17259670) | <0.01 | 0.02 | ||||||||||||
| AA | 224 | 156 | 1.00 | 406 | 319 | 0.96 | (0.73, 1.26) | 200 | 166 | 0.76 | (0.50, 1.13) | |||
| AG/GG | 22 | 40 | 2.65 | (1.53, 4.70) | 66 | 46 | 0.84 | (0.54, 1.31) | 41 | 27 | 0.65 | (0.35, 1.17) | ||
1
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, center, race, sex, and kcal. Percentiles based on sex and study.
2
Similar associations for MAPK14 rs851016 (r2=0.99)