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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Science. 2012 Apr 13;336(6078):237–240. doi: 10.1126/science.1215691

Figure 2.

Figure 2

Time resolved progression of miRNA-mediated gene silencing establishes that repression of protein synthesis precedes mRNA deadenylation and decay. (A-D) Normalized levels of protein amounts for both miRNA-targeted (T) and non-targeted (NT) constructs; normalized mRNA levels for reporter genes from oligo(dT)25 resin pull down or from total RNA presented as ratios of poly(A) and total mRNA, respectively. Each data point represents the mean value ± standard deviation calculated from three independent experiments,