Skip to main content
. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Bioessays. 2010 Sep;32(9):756–767. doi: 10.1002/bies.201000027

Figure 2.

Figure 2

Genomic insertion preferences of integrating vector systems. Genomic integration of viral vector systems shows considerable preference for genes [8–10, 111]. In contrast, SB integration can be considered fairly random on a genomic level [37, 40]. Only about one-third of SB insertions occur in transcribed regions (the vast majority in introns), suggesting that SB might be a safer vector for therapeutic gene delivery than most viruses that are currently used. The genomic integration profile of piggyBac [33] or Tol2 resembles that of integrating viral vectors [30].