Table 2.

Hydrodynamic infusion to liver

Model	Method	DNA mg (µg/g)	VOL (ml/sec)	RATE	References
Mouse (0.02–0.03 kg)
	Tail-vein	0.025 (1)*	2 ml	>0.2 ml/sec	[60, 61, 64]
Rat (0.2–0.3 kg)
	IVC catheter	0.8 (80)	15 ml	0.4 ml/sec	[97]
	IVC catheter	0.15 (110)	3 ml	0.4 ml/sec	[112]
	IVC catheter	0.8 (100)	16 ml	~2 ml/sec	[113]
Rabbit (~3–4 kg)
	IVC catheter	60 (2)	60 ml	~2 ml/sec	[94]
Dog (~5–20 kg)
	IVC catheter	10–30 (90)	600 ml	~2 ml/sec	[97, 98]
	IVC catheter	11 (110)	200 ml	20 ml/sec	[103]
Pig (~20–30 kg)
	IVC catheter	3 (6)	150 ml	5 ml/sec	[114]
	IVC catheter	4 (5)	100 ml	7.5 ml/sec	[100]
	SVC catheter	20–50 (33–80)	300 ml	20 ml/sec	[115]
	IVC catheter	18 (40)	370 ml	1.7 ml/sec	[116]
	SLL** catheter	80 (320)	800 ml	40 ml/sec	[101]
	SLL** catheter	60 (~300)	600 ml	40 ml/sec	[102]
Human (n = 14)
	Hepatic vein catheter	1–45*	50–300 ml	>1–6 ml/sec	[115]

^*Amounts of infused DNA are calculated per weight of the targeted tissue, except where denoted by an asterisk, in which case amounts are for the entire animal. Unless data are specifically reported, the values for DNA delivered per kg target organ weight were calculated assuming the liver was 3% the weight of rabbits, dogs and pigs.

^**Selected liver lobe.