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. 2014 Mar 3;124(4):1622–1635. doi: 10.1172/JCI71386

Figure 3. Diseased ECM coordinately activates the translation of ECM region genes.

Figure 3

(A–D) Modulation of genes in the ECM region gene ontology. Upper panels show volcano plots of ECM and cell effects at the translation and steady-state RNA levels. The number of genes up- or downregulated (P < 0.05) is indicated. Lower panels show cumulative P value probability distributions from the same comparisons. Dotted line indicates the theoretical null distribution. Solid black line indicates the distribution for all genes. Red line represents the distribution for those genes in the ECM region gene ontology.