Figure 4. Converging and independent modulation of ECM gene translation is dependent upon ECM and cell origins.

(A) Translation (ANOTA-corrected) and steady-state RNA profiles of genes in the ECM region gene ontology that were differentially expressed (P < 0.05) in any comparison. Values are log₁₀P values (yellow denotes upregulation in IPF, blue denotes downregulation). (B) Close-up of the translation profile. Genes are divided into three categories: cell-regulated, ECM-regulated, and coregulated. Density plots of the absolute fold changes induced by each biological variable are shown. Selected gene ontologies that are overrepresented (P < 0.01, calculated using Fisher’s exact test) are shown (see Supplemental Table 2 for the complete list). There were no significantly overrepresented gene ontologies in the cell-regulated group. (C) Same analysis for the steady-state RNA profile.