Table 3.
—OR of SSRI/SNRI vs Control for Multivariate Logistic Regression for Hospital Mortality
| Patient Subgroup | Population Total (Control/Positive) | OR | 95% CI | P Value |
| Entire cohorta | 14,709 (12,238/2,471) | 1.19 | (1.02-1.40) | .026 |
| Comorbidities by ICD-9 | ||||
| Cardiovascular diseasea | 10,195 (8,521/1,674) | 1.24 | (1.03-1.49) | .025 |
| Diabetes mellitus | 2,571 (2,063/508) | 1.08 | (0.75-1.58) | .7 |
| Selected ICU types | ||||
| CSRUa | 5,463 (4,647/816) | 1.45 | (1.07-1.95) | .016 |
| MICU | 5,000 (4,006/994) | 1.05 | (0.83-1.34) | .7 |
| Selected acute diagnoses | ||||
| Acute coronary syndromea (serum troponin > 0.5 ng/mL) | 1,171 (990/181) | 1.95 | (1.21-3.13) | .006 |
| Acute renal failure by ICD-9 | 2,071 (1,670/401) | 1.22 | (0.90-1.66) | .2 |
| Acute respiratory failure by ICD-9 | 1,847 (1,448/399) | 1.05 | (0.79-1.38) | .7 |
| Sepsis (Martin criteria) | 509 (420/89) | 1.31 | (0.67-2.54) | .4 |
Each row was obtained from the regression model for the specific patient subset. See Table 1 legend for expansion of abbreviations.
a
These results reject the null hypothesis using Holm’s stepdown procedure on the families previously defined, with an initial P value of .05 for the entire cohort of < .05.