Table 3.
MicroRNAs interfering with the expression of transporters of the ABC C and E family
| ABC transporter | MicroRNA | Effect of miRNA on gene expression | Mechanism | Tissue | Reference |
|---|---|---|---|---|---|
| ABCC1 | miR-326 | ABCC1↓ | * | MCF-7 human breast cancer cells, breast cancer tissue | 54 |
| miR-199a/b and miR-296 | ABCC1↓ | * | Hepatocellular carcinoma | 58 | |
| ABCC2 | miR-297 | ABCC2↓ | * | Human ileocaecal colorectal adenocarcinoma cell line HCT-8 and human colorectal cancer cell line HCT-116 | 55 |
| miR-379 | ABCC2↓ | * | HepG2 human hepatoblastoma cells | 56 | |
| ABCC3 | miR-9* | ABCC3↓ | Indirect, via ID4 and SOX2* | Glioma cell lines (A172, A1207, LN18 and LN229) and human glioma stem cells derived from patients with glioma | 57 |
| ABCC4 | miR-125a/b | ABCC4↓ | *(weak) | Hepatocellular carcinoma | 58 |
| ABCC5 | miR-101, miR-125a and let-7a | ABCC5↓ | * | Hepatocellular carcinoma | 58 |
| ABCC6 | miR-9* | ABCC6↓ | Indirect, via ID4 and SOX2* | Glioma cell lines (A172, A1207, LN18 and LN229) and human glioma stem cells derived from patients with glioma | 57 |
| ABCC10 | let-7a/e | ABCC10↓ | * | Hepatocellular carcinoma | 58 |
| ABCE1 | miR-26a, miR-135b and miR-145 | ABCE1↓ | * | Hepatocellular carcinoma | 58 |
ID4, inhibitor of differentiation 4; SOX2, SRY (sex determining region Y)-box 2. Symbols are as follows: ++, indirect, exact mechanism unknown.
*
Confirmed mRNA/miRNA interference by 3′-UTR reporter gene assay.