Table 3.

The genes and associated coding variants that have been found to be associated with drug-induced arrhythmias

Genes	Associated phenotype	Variants	Functional assessment	Studies
SCN5A	LQT3	S1102Y	Yes	Splawski et al., 2002 23
		G1844A, C1852T, T3748C	Yes	Yang et al., 2002 25
KCNH2	LQT2	C2350T	Yes	Yang et al., 2002 25
		P347S	Yes	Paulussen et al., 2004 26
		R1033W	No	Ramirez et al., 2012 30
KCNQ1	LQT1	C1747T	Yes	Yang et al., 2002 25
		Y315C	Yes	Napolitano et al., 2000 24
KCNE1	LQT5	D85N	Yes	Paulussen et al., 2004 26 and Kaab et al., 2011 4
KCNE2	LQT6	T8A	Yes	Paulussen et al., 2004 26, Sesti et al., 2000 21, Abbott et al., 1999 22
NOS1AP	QT interval	rs10919035†	Yes	Jamshidi et al., 2012 42
CACNA1C	LQT8	A1733V	No	Ramirez et al., 2012 30
AKAP9	LQT11	Q3531E	No	Ramirez et al., 2012 30
SNTA1	LQT12	T147N	No	Ramirez et al., 2012 30
KCND3	Brugada syndrome	R566C	No	Ramirez et al., 2012 30
GPD1L	Brugada syndrome	V249M	No	Ramirez et al., 2012 30
RYR2	Catecholaminergic polymorphic ventricular tachycardia	L555V, L2607P, E4361Q	No	Ramirez et al., 2012 30
CACNB2	Short QT syndrome	M1V, I170V	No	Ramirez et al., 2012 30
KCNN3	Atrial fibrillation	F315L	No	Ramirez et al., 2012 30
PPP2R3A		F1000L	No	Ramirez et al., 2012 30
AKAP7		Q112R	No	Ramirez et al., 2012 30
APLP2		R504L	No	Ramirez et al., 2012 30
ATP2A2		S184C	No	Ramirez et al., 2012 30
AKAP6		V839A	No	Ramirez et al., 2012 30
ZFHX3		K3689E, T3640M, H3611Y, L741F, G117S	No	Ramirez et al., 2012 30
JPH3		R656W	No	Ramirez et al., 2012 30
CALR		D165G	No	Ramirez et al., 2012 30
JPH2		V345L, T286A	No	Ramirez et al., 2012 30

LQTX, subtype of the congenital long QT syndrome;

^†Non-coding variant associated with dLQTS.